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Jan 16, 2024 | UCI Health
OCMA honors UCI Health 'Physicians of Excellence'
UCI Health is home to more than 190 doctors who have been named 2024 Physicians of Excellence by the Orange County Medical Association (OCMA), more than any other hospital in the region.
Jan 11, 2024 | UCI Health Gavin Herbert Eye Institute Shine the Light
Philanthropists reflect on the eye institute they helped build
Seen by many as the father of Orange County’s thriving ophthalmic industry, Gavin Herbert co-founded the pharmaceutical company Allergan and brought it to Irvine in 1966, just as the University of California opened a new campus on land that had been part of the historic Irvine Ranch. He helped recruit internationally renowned glaucoma researcher Irving Leopold, MD, as founding chair of the UCI School of Medicine’s Department of Ophthalmology, bringing instant prestige to the fledgling program. Since the opening of the eye institute in 2013, Gavin and Ninetta Herbert have continued to support UCI’s excellence in ophthalmology. While Gavin Herbert focuses on research breakthroughs, Ninetta Herbert’s heart is with saving the vision of the next generation. Click below to read more as they reflect on their journey and their current efforts.'
Jan 09, 2024 | UCI News
School of Medicine Receives Prestigious Grant from Research to Prevent Blindness
The University of California, Irvine School of Medicine has received a prestigious Unrestricted Grant from the nonprofit organization Research to Prevent Blindness. The five-year, $575,000 grant will support eye research conducted by the Department of Ophthalmology.
Jan 02, 2024 | UCI Health Gavin Herbert Eye Institute Shine the Light
Specialist in rare eye cancers joins UCI Health
Kapil Mishra, MD, is like a missing puzzle piece. The new UCI Health ophthalmologist’s expertise in certain cancers of the eye was the last ophthalmic subspecialty needed at the Gavin Herbert Eye Institute. Until now.
Nov 30, 2023 | UCI Health Gavin Herbert Eye Institute Shine the Light
A painter’s sight preserved
When Mary McKay Schaffer arrived for a routine visit with Dr. Sameh Mosaed, she had no idea that she'd be receiving a life-saving diagnosis. Read about the moment Dr. Mosaed identified a serious complication and took swift action to save more than just her vision.
Nov 28, 2023 | UCI Health Gavin Herbert Eye Institute Shine the Light
Q&A: New horizons for glaucoma research
Sight-saving treatments begin at sight-saving research. Hear from our newest research Principle Investigator, Dr. Gulab Zode, in this Q&A.
Oct 25, 2023 | UCI Health Gavin Herbert Eye Institute
UCI Gavin Herbert Eye Institute 10 Year Anniversary
September 2023 marks the 10th Anniversary of the opening of the Gavin Herbert Eye Institute. This commemorative video looks at the inspiration and accomplishments of the institute and highlights our growth and groundbreaking research, all aimed at creating a positive impact within our local community and on a global scale.
Oct 13, 2023 | UCI News
A decade of visionary achievement
UCI’s Gavin Herbert Eye Institute celebrates its 10th anniversary.
Oct 10, 2023 | Review of Ophthalmology
What to do with a White Cataract
The challenges to expect and tips for successful management of these complicated cases.
Aug 29, 2023 | Cell Reports Journal
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia
In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor (RGR) photoisomerase, which is expressed in both the retinal pigment epithelium (RPE) and in Müller cells. The relative contributions of these two cellular pools of RGR to the maintenance of photoreceptor light responses are not known. Here, we use a cell-specific gene reactivation approach to elucidate the kinetics of RGR-mediated recovery of photoreceptor responses following light exposure. Electroretinographic measurements in mice with RGR expression limited to either cell type reveal that the RPE and a specialized subset of Müller glia contribute both to scotopic and photopic function. We demonstrate that 11-cis-retinal formed through photoisomerization is rapidly hydrolyzed, consistent with its role in a rapid visual pigment regeneration process. Our study shows that RGR provides a pan-retinal sink for all-trans-retinal released under sustained light conditions and supports rapid chromophore regeneration through the photic visual cycle.