Oct 19, 2020 | National Eye Institute
UCI-led study reveals significant restoration of retinal and visual function following gene therapy
UCI researchers working on a breakthrough study have results showing the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.
Aug 12, 2015
UCI-led team begins first clinical trial of stem cell-based retinitis pigmentosa treatment
UC Irvine’s Dr. Henry Klassen leads first clinical trial of stem cell-based retinitis pigmentosa treatment.
Manager, Communications and Public Relations
A special antibody derived from Llamas - called a nanobody - can stop the misfolding and the activation of Rhodopsin, a molecule whose mutations can lead to blindness
One of our collaboration opportunities at UCI Health Gavin Herbert Eye Institute is Neuro-ophthalmology. Hear from Chief of Neuro-ophthalmology, Dr. Vivek Patel, in this Q&A.
How often you get an eye exam depends on age, symptoms and existing vision problems. Here's what doctors recommend for good eye health.
Aug 29, 2023 | Cell Reports Journal
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia
In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor (RGR) photoisomerase, which is expressed in both the retinal pigment epithelium (RPE) and in Müller cells. The relative contributions of these two cellular pools of RGR to the maintenance of photoreceptor light responses are not known. Here, we use a cell-specific gene reactivation approach to elucidate the kinetics of RGR-mediated recovery of photoreceptor responses following light exposure. Electroretinographic measurements in mice with RGR expression limited to either cell type reveal that the RPE and a specialized subset of Müller glia contribute both to scotopic and photopic function. We demonstrate that 11-cis-retinal formed through photoisomerization is rapidly hydrolyzed, consistent with its role in a rapid visual pigment regeneration process. Our study shows that RGR provides a pan-retinal sink for all-trans-retinal released under sustained light conditions and supports rapid chromophore regeneration through the photic visual cycle.
Apr 25, 2023 | Forbes Health
Red Eyes (Bloodshot Eyes): Causes And Treatment
Red eyes, also called bloodshot eyes, can be caused by various factors and are a common issue most people experience at some point. It’s important to understand the possible reasons behind red eyes because while some underlying causes are harmless, others can indicate a medical concern, be contagious and/or require medical attention.
No results found.