Feb 22, 2024 | UCI News
UC Irvine study shows similarities and differences in human and insect vision formation
Discovery offers insights into retinal disease origins and potential therapeutic targets.
Jan 09, 2024 | UCI News
School of Medicine Receives Prestigious Grant from Research to Prevent Blindness
The University of California, Irvine School of Medicine has received a prestigious Unrestricted Grant from the nonprofit organization Research to Prevent Blindness. The five-year, $575,000 grant will support eye research conducted by the Department of Ophthalmology.
Oct 19, 2020 | National Eye Institute
UCI-led study reveals significant restoration of retinal and visual function following gene therapy
UCI researchers working on a breakthrough study have results showing the restoration of retinal and visual functions of mice models suffering from inherited retinal disease.
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Chief of Pediatric Ophthalmology at UCI Health Gavin Herbert Eye Institute, Donny Suh, MD whom leads it's Eye Mobile for Children develops special eye wear for kids. Made with a 3D printer, these inexpensive spectacles provide vision correction for children with head or facial abnormalities who are unable to wear regular frames, as well as kids whose families who can't afford glasses.
UCI professor and Director of the Laboratory of Cellular and Molecular immunology at the Gavin Herbert Eye Institute, Lbachir BenMohamed, PhD, alongside colleagues across the UCI School of Medicine have demonstrated in pre-clinical studies that combining their broad-based antigen approach with current COVID-19 vaccines gives better protection against illness from repeated infection by many virus variants. BenMohamed points out that SARS-CoV-2 is unlikely to be the last coronavirus to cause widespread disease. He hopes that his lab’s vaccine approach will make it possible to respond quickly with effective therapies when the need arises.
UCI Health is home to more than 190 doctors who have been named 2024 Physicians of Excellence by the Orange County Medical Association (OCMA), more than any other hospital in the region.
Oct 10, 2023 | Review of Ophthalmology
What to do with a White Cataract
The challenges to expect and tips for successful management of these complicated cases.
Aug 29, 2023 | Cell Reports Journal
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia
In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor (RGR) photoisomerase, which is expressed in both the retinal pigment epithelium (RPE) and in Müller cells. The relative contributions of these two cellular pools of RGR to the maintenance of photoreceptor light responses are not known. Here, we use a cell-specific gene reactivation approach to elucidate the kinetics of RGR-mediated recovery of photoreceptor responses following light exposure. Electroretinographic measurements in mice with RGR expression limited to either cell type reveal that the RPE and a specialized subset of Müller glia contribute both to scotopic and photopic function. We demonstrate that 11-cis-retinal formed through photoisomerization is rapidly hydrolyzed, consistent with its role in a rapid visual pigment regeneration process. Our study shows that RGR provides a pan-retinal sink for all-trans-retinal released under sustained light conditions and supports rapid chromophore regeneration through the photic visual cycle.
No results found.